A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

NCT ID: NCT05514054

This clinical trial is studying a new treatment called imlunestrant to see how well it works compared to standard hormone therapy for patients with early breast cancer. The patients being considere...

Recruiting

Phase: PHASE3 Conditions: Breast Neoplasms

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

NCT ID: NCT05987241

The MODERN study is a clinical trial designed to explore how a blood test can help identify bladder cancer patients who may need additional treatment after having their bladder surgically removed. ...

Recruiting

Phase: PHASE2 Conditions: Stage III Bladder Urothelial Carcinoma AJCC v6 and v7, Stage IV Bladder Urothelial Carcinoma AJCC v7 +5 more

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT ID: NCT06890598

This clinical trial is studying a new treatment called olomorasib, which is being tested alongside standard treatments for patients with a specific type of lung cancer known as KRAS G12C-mutant non...

Recruiting

Phase: PHASE3 Conditions: Carcinoma, Non-Small-Cell Lung

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

NCT ID: NCT07076121

This clinical trial is studying a new treatment option for people with a type of advanced pancreatic cancer called metastatic pancreatic ductal adenocarcinoma (PDAC). Specifically, it’s looking at ...

Not yet recruiting

Phase: PHASE2 Conditions: Pancreatic Ductal Adenocarcinoma

Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

NCT ID: NCT06635785

The clinical trial titled "BIPAVE-001" is studying a new treatment called AI-081, which is a special type of antibody designed to target certain proteins in advanced solid tumors. This trial is cur...

Recruiting

Phase: PHASE1 Conditions: Advanced Solid Tumor

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

NCT ID: NCT06096844

The ACHIEVE Trial is a clinical study designed to find out if combining chemotherapy with an immunotherapy drug called pembrolizumab is more effective than using immunotherapy alone for older adult...

Recruiting

Phase: PHASE3 Conditions: Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 +2 more

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT ID: NCT04728893

This clinical trial is studying a new medication called nemtabrutinib (MK-1026) to see how safe and effective it is for people with certain blood cancers, including chronic lymphocytic leukemia (CL...

Recruiting

Phase: PHASE2 Conditions: Hematologic Malignancies, Non-Hodgkins Lymphoma +2 more

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

NCT ID: NCT06119581

This clinical trial is investigating whether a new drug called LY3537982, combined with standard cancer treatments like immunotherapy and chemotherapy, is more effective for patients with advanced ...

Recruiting

Phase: PHASE3 Conditions: Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

NCT ID: NCT06312137

This clinical trial is investigating whether a combination of two treatments, pembrolizumab and sacituzumab tirumotecan, can help patients with a type of lung cancer called non-small cell lung canc...

Recruiting

Phase: PHASE3 Conditions: Non Small Cell Lung Cancer

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT ID: NCT04389632

This clinical trial is studying a new drug called sigvotatug vedotin (SGN-B6A) to see how safe it is and if it can help treat various advanced solid tumors, such as lung cancer, breast cancer, and ...

Recruiting

Phase: PHASE1 Conditions: Ovarian Neoplasms, Esophageal Squamous Cell Carcinoma +10 more

Food Provision in Prenatal Care

NCT ID: NCT06711627

This clinical trial is studying whether providing healthy food to pregnant women can help prevent excessive weight gain during pregnancy. Researchers want to find out if women who receive food supp...

Recruiting

Phase: NA Conditions: Pregnancy Complications, Excessive Gestational Weight Gain

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

NCT ID: NCT05538130

This clinical trial is studying a new medicine called PF-07799544 to see how safe and effective it is for people with advanced solid tumors, such as melanoma, brain cancer, thyroid cancer, and lung...

Recruiting

Phase: PHASE1 Conditions: Colorectal Cancer, Melanoma +5 more

A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

NCT ID: NCT06638307

This clinical trial is testing a new treatment called MEN2312 for adults with advanced breast cancer, which means the cancer has spread and cannot be cured. MEN2312 is a type of medication that tar...

Recruiting

Phase: PHASE1 Conditions: Advanced Breast Cancer

4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

NCT ID: NCT06864988

This clinical trial is studying a treatment called 4D-150 for adults with a specific eye condition known as macular neovascularization (MNV) that can occur due to age-related macular degeneration (...

Recruiting

Phase: PHASE3 Conditions: Macular Neovascularization Secondary to Age-Related Macular Degeneration

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NCT ID: NCT05095376

This clinical trial is studying whether adding a chemotherapy drug called lomustine (Gleostine®) to the usual treatment of temozolomide and radiation therapy can help patients with newly diagnosed ...

Recruiting

Phase: PHASE3 Conditions: Glioblastoma, Gliosarcoma

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

NCT ID: NCT05947851

This clinical trial is investigating a new treatment for patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is comparing two trea...

Recruiting

Phase: PHASE3 Conditions: Leukemia, Lymphocytic, Chronic, B-Cell, CLL +4 more

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

NCT ID: NCT04613596

The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 par...

Recruiting

Phase: PHASE2 Conditions: Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

NCT ID: NCT06856577

This clinical trial is studying a new treatment called Ixoberogene Soroparvovec (Ixo-vec) for people with a specific eye condition known as neovascular age-related macular degeneration (nAMD), whic...

Recruiting

Phase: PHASE3 Conditions: Wet AMD, Neovascular Age-Related Macular Degeneration (nAMD)

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

NCT ID: NCT06961006

This clinical trial is studying a new combination treatment for advanced melanoma, which is a serious form of skin cancer that has spread and cannot be removed by surgery. The researchers want to f...

Recruiting

Phase: PHASE2 Conditions: Malignant Melanoma

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

NCT ID: NCT05355701

This clinical trial is studying a new medicine called PF-07799933 to see how safe it is and how well it works for people with advanced solid tumors that have a specific gene change known as a "BRAF...

Recruiting

Phase: PHASE1 Conditions: Melanoma, Glioma +2 more

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Clinical Trials in Springdale, Arkansas

54 Active Trials Found in Springdale

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Food Provision in Prenatal Care

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.