Clinical Trials for Colorectal Neoplasms

Find clinical trials for colorectal neoplasms. Discover research opportunities and treatment options in your area.

106 Active Trials Found

Showing 106 trials on this page

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A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

NCT ID: NCT06750094

This clinical trial is exploring a new treatment option for patients with colorectal cancer that has not responded to previous chemotherapy. Specifically, it is comparing the effectiveness of a com...

Recruiting

Phase: PHASE3 Type: interventional Locations: Saint Louis, Missouri, United States, Philadelphia, Pennsylvania, United States +193 more

A Study of SGN-MesoC2 in Advanced Solid Tumors

NCT ID: NCT06466187

This clinical trial is looking at a new treatment called SGN-MesoC2 for people with advanced solid tumors, which are types of cancer that start in organs like the lungs, pancreas, or ovaries. The s...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Scottsdale, Arizona, United States +21 more

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

NCT ID: NCT04222413

This clinical trial is studying a new drug called metarrestin, which researchers hope can help stop cancer cells from growing and spreading, particularly in patients with advanced solid tumors like...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States, Fairway, Kansas, United States

Preventing Early-Onset Colorectal Cancer in the VA

NCT ID: NCT07071454

This clinical trial is focused on finding better ways to prevent early-onset colorectal cancer (CRC) in Veterans aged 45 to 49. Colorectal cancer is a common and serious disease, and recently, more...

Not yet recruiting

Phase: NA Type: interventional Locations: New York, New York, United States

A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.

NCT ID: NCT06704724

This clinical trial is studying a new medicine called PF-07985045 to see how safe it is and how well it works in treating advanced solid tumors, which are lumps of abnormal cells in the body. The t...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +13 more

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

NCT ID: NCT05253651

This clinical trial is testing a new treatment approach for patients with HER2 positive colorectal cancer that has spread to other parts of the body and cannot be surgically removed. The study is c...

Recruiting

Phase: PHASE3 Type: interventional Locations: Rochester, Minnesota, United States, Los Angeles, California, United States +663 more

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

NCT ID: NCT05983133

This clinical trial is investigating a new drug called SGN-EGFRd2, aimed at treating patients with advanced solid tumors, including certain types of colorectal cancer, lung cancer, and pancreatic c...

Recruiting

Phase: PHASE1 Type: interventional Locations: Iowa City, Iowa, United States, Tampa, Florida, United States +33 more

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

NCT ID: NCT01915225

This clinical trial is focused on collecting tissue samples from patients with certain types of cancer, including colorectal, gastric, bile duct, and pancreas cancers. Researchers need these sample...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)

NCT ID: NCT05239741

This clinical trial is studying two different treatment options for patients with advanced stage IV colorectal cancer, specifically those with a certain genetic condition known as Microsatellite In...

Recruiting

Phase: PHASE3 Type: interventional Locations: Beijing, Beijing, China, Nanjing, Jiangsu, China +53 more

Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver

NCT ID: NCT02885753

This clinical trial is studying a combination of different chemotherapy treatments for patients with colorectal cancer that has spread to the liver and cannot be surgically removed. The goal is to ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Strasbourg, , France, Le Havre, , France +137 more

First in Human Study of AZD9592 in Solid Tumors

NCT ID: NCT05647122

This clinical trial, called the First in Human Study of AZD9592, is exploring a new treatment for patients with advanced solid tumors, including types of lung, head and neck, and colorectal cancers...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, New York, New York, United States +47 more

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

NCT ID: NCT06662786

This clinical trial is examining two different treatment options for adults with advanced left-sided colorectal cancer that cannot be surgically removed. The researchers want to find out which trea...

Recruiting

Phase: PHASE3 Type: interventional Locations: Paris, , France, Saint Louis, Missouri, United States +214 more

Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques

NCT ID: NCT07035587

This clinical trial is studying a new blood test that aims to detect several types of cancer early and to monitor patients after treatment to see if any cancer remains or returns. The test looks fo...

Recruiting

Type: observational Locations: Seoul, , Korea, Republic Of

Early Detection of Advanced Adenomas and Colorectal Cancer

NCT ID: NCT06342440

This clinical trial is looking to create a new blood test that can help find colorectal adenomas (precancerous growths) and colorectal cancer early. The goal is to make this test highly sensitive a...

Recruiting

Type: observational Locations: San Diego, California, United States, Milan, , Italy +4 more

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

NCT ID: NCT04008797

This clinical trial is investigating a new treatment called E7386, which is being tested in combination with other cancer drugs for patients with solid tumors, including liver cancer, colorectal ca...

Recruiting

Phase: PHASE1 Type: interventional Locations: Charleston, South Carolina, United States, Los Angeles, California, United States +118 more

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

NCT ID: NCT06447662

This clinical trial is studying a new medication called PF-07934040 to understand how safe it is and how well it works for people with advanced solid tumors that have a specific genetic change know...

Recruiting

Phase: PHASE1 Type: interventional Locations: Durham, North Carolina, United States, Saint Louis, Missouri, United States +24 more

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

NCT ID: NCT06131840

This clinical trial is investigating an experimental drug called PF-08046050, which is designed to treat adults with advanced solid tumors, including types of cancer like colorectal, stomach, pancr...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Boston, Massachusetts, United States +49 more

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

NCT ID: NCT05612347

This clinical trial is comparing two methods for monitoring older adults who have had colon polyps: annual stool testing (called FIT) and colonoscopy. It focuses on adults aged 65 to 82 who have a ...

Recruiting

Phase: NA Type: interventional Locations: Chicago, Illinois, United States, Aurora, Colorado, United States +15 more

HTL0039732 in Participants With Advanced Solid Tumours

NCT ID: NCT05944237

This clinical trial is studying a new drug called HTL0039732 to see how it works for people with advanced solid tumors, which are types of cancer that form in various organs, like the prostate, sto...

Recruiting

Phase: PHASE1 Type: interventional Locations: London, , United Kingdom, Cambridge, , United Kingdom +3 more

Iparomlimab/Tuvonralimab Combined With Bevacizumab and CAPEOX as Conversion Therapy for Colorectal Cancer Liver Metastasis

NCT ID: NCT07007728

This clinical trial is studying a new treatment approach for patients with colorectal cancer that has spread to the liver, specifically looking at those with certain genetic features. The treatment...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, Beijing, China

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