Clinical Trials for Esophageal Neoplasms

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

NCT ID: NCT06469944

This clinical trial is exploring how safe and effective a combination of three treatments—sacituzumab tirumotecan, pembrolizumab, and a type of chemotherapy—can be for patients with certain types o...

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

NCT ID: NCT06445972

This clinical trial is exploring new treatment options for patients with advanced esophageal or stomach cancer who have not responded to their first treatment. Specifically, the study is comparing ...

HTL0039732 in Participants With Advanced Solid Tumours

NCT ID: NCT05944237

This clinical trial is studying a new drug called HTL0039732 to see how it works for people with advanced solid tumors, which are types of cancer that form in various organs, like the prostate, sto...

Effects of Preoperative Enteral Immunonutrition for Esophageal Cancer Patients Given Neoadjuvant Chemoradiotherapy

NCT ID: NCT04513418

This clinical trial is studying the effects of a special diet, called enteral immunonutrition, for patients with esophageal cancer who are about to undergo chemotherapy and radiation therapy before...

Esophageal Cancer Multimodal Prehabilitation Study

NCT ID: NCT06027515

The Esophageal Cancer Multimodal Prehabilitation Study is a research trial aimed at helping older patients with esophageal cancer get ready for surgery. The study will explore a prehabilitation pro...

Comparative Study Between (FC-SEMS) and (PC-SEMS) in the Palliation of Dysphagia Due to Malignant Neoplasm of Esophagus.

NCT ID: NCT06070376

This clinical trial is investigating two types of esophageal prostheses, known as fully covered self-expanding metal stents (FC-SEMS) and partially covered self-expanding metal stents (PC-SEMS), to...

Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections

NCT ID: NCT06077981

This clinical trial is looking at two different solutions, hyaluronic acid and hydroxyethylamide, to see which one works better during a specific type of surgery called endoscopic submucosal resect...

Mayo Clinic Upper Digestive Disease Survey

NCT ID: NCT02530983

The Mayo Clinic Upper Digestive Disease Survey is a clinical trial designed to help improve the care of patients with esophageal conditions, including esophageal cancer. This study is focused on cr...

The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study

NCT ID: NCT05804331

This clinical trial, called the Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study, is looking at the long-term effects of different procedures used to r...

Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)

NCT ID: NCT06862479

Assessment of Response to nCRT for GEJ Cancer Using a Fully Integrated PET/MRI

NCT ID: NCT04359732

This clinical trial is looking at how a special type of imaging called PET/MRI can help doctors predict how well patients with esophageal or junctional cancers will respond to a specific treatment ...

Rehabilitation and Recovery for Persons with Esophageal or Gastric Cancer

NCT ID: NCT05698992

This clinical trial is focused on improving the recovery process for people diagnosed with esophageal or gastric cancer. The goal is to create a rehabilitation program that can help enhance quality...

Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms

NCT ID: NCT06643689

The TAPES clinical trial is studying whether a medication called tranilast can help prevent a condition known as esophageal stricture, which can occur after a specific type of treatment for certain...

Fruquintinib in Combination With Tislelizumab Followed by Radiotherapy in Esophageal Squamous Cell Carcinoma

NCT ID: NCT06646588

This clinical trial is investigating a new treatment approach for patients with advanced esophageal squamous cell carcinoma, a type of cancer that affects the esophagus. The study is looking at a c...

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

NCT ID: NCT06380816

This clinical trial is testing a new drug called UCB4594 in people with advanced cancer. UCB4594 is a monoclonal antibody, which means it's designed to attach to a specific protein found in high am...

Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers

NCT ID: NCT05688176

This clinical trial is looking for new ways to diagnose two conditions: Barrett's esophagus, which is a change in the cells lining the esophagus, and esophageal adenocarcinoma, a type of cancer. Th...

PD-1 Inhibitor Plus Chemotherapy With or Without Radiotherapy in Patients With Metastatic Esophageal Cancer

NCT ID: NCT06086457

This clinical trial is studying a new treatment approach for patients with advanced esophageal cancer, specifically stage IVb, which means the cancer has spread to distant parts of the body. Resear...

Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)

NCT ID: NCT04654975

The METABREC clinical trial is studying brain metastases, which are cancer cells that have spread to the brain, in patients who have undergone esophagectomy (surgery to remove part or all of the es...

Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.

NCT ID: NCT06365866

This clinical trial is looking at a new treatment option for patients with thoracic esophageal cancer. Researchers want to see how well a special type of radiation therapy called intraluminal brach...

Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow During Esophageal Surgery in Humans

NCT ID: NCT05591053

This clinical trial is studying a new imaging technology called ActivSight™, which helps surgeons see blood flow and tissue health during esophageal surgery. The aim is to find out if this technolo...