Clinical Trials for Major Depressive Disorder

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

NCT ID: NCT06564818

This clinical trial is studying a new treatment called CYB003, which is a type of psilocybin analog, for people with Major Depressive Disorder (MDD). The goal of the study is to see if CYB003 is ef...

Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression

NCT ID: NCT06419608

This clinical trial is studying a new treatment called BHV-7000 for people with Major Depressive Disorder (MDD). The goal is to see how well this treatment works and how safe it is for individuals ...

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT ID: NCT06029439

This clinical trial, named NMRA-335140-501, is studying a new treatment called NMRA-335140 for people with Major Depressive Disorder (MDD). It is an extension of previous studies that looked at how...

Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

NCT ID: NCT06058013

This clinical trial is investigating a new medication called NMRA-335140 to see how well it helps people with Major Depressive Disorder (MDD). Participants in the study will be randomly assigned to...

Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder

NCT ID: NCT06058039

This clinical trial is studying a new medication called NMRA-335140 to see how well it helps people with Major Depressive Disorder (MDD) feel better. The trial is in its third phase, meaning it is ...

A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder

NCT ID: NCT06254612

This clinical trial is studying a new treatment called SP-624 for adults who have Major Depressive Disorder (MDD), a serious condition that affects mood and daily life. The trial is in its second p...

A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge)

NCT ID: NCT06941844

The Emerge trial is a research study looking at a new treatment called MM120 for people with Major Depressive Disorder (MDD). This study is in its final phase, which means it’s testing how well MM1...

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

NCT ID: NCT06559826

This clinical trial is studying two different ways to treat Major Depressive Disorder (MDD) using ketamine, a medication known for its rapid antidepressant effects. One group of participants will r...

Imaging Depression in Parkinson's Disease

NCT ID: NCT06402955

This clinical trial, titled "Imaging Depression in Parkinson's Disease," is focused on understanding how depression affects people with Parkinson's Disease (PD). The study aims to identify specific...

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT ID: NCT06462196

This clinical trial is studying mood disorders like depression and bipolar disorder, which are often hard to treat effectively. Researchers are looking to understand how these conditions affect pat...

JAK Signaling in Depression

NCT ID: NCT07003997

This clinical trial, titled "JAK Signaling in Depression," is investigating how a medication called baricitinib, which inhibits a specific signaling pathway in the body (known as JAK signaling), ca...

Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)

NCT ID: NCT06423781

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

NCT ID: NCT05437588

This clinical trial is looking at how certain markers in the blood, called microRNAs, can help us understand depression and suicidal thoughts in teenagers. The goal is to identify these markers to ...

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

NCT ID: NCT05172271

This clinical trial is studying a new treatment called Transcranial Electric Stimulation Therapy (TEST) for people who have major depression and haven’t found relief from current treatments. The go...

Antidepressant Response of DMT Masked With Propofol

NCT ID: NCT06927076

This clinical trial is studying the effects of a substance called N,N-dimethyltryptamine (DMT) on individuals with Major Depressive Disorder (MDD). The researchers want to find out if DMT helps red...

Mood Effects of Serotonin Agonists: Depression

NCT ID: NCT07017478

This clinical trial is looking at how a low dose of LSD, a substance known to affect mood, can help people with major depression. Researchers want to see how this drug impacts feelings of sadness a...

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

NCT ID: NCT05850689

This clinical trial is studying a medication called Lumateperone to see if it can help people with Major Depressive Disorder (MDD) who aren't getting enough relief from their current antidepressant...

Neural Circuit Effects of Ketamine in Depression

NCT ID: NCT06213324

This clinical trial, titled "Neural Circuit Effects of Ketamine in Depression," is looking into how a specific part of the brain, called the subgenual anterior cingulate cortex (sgACC), affects fee...

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT ID: NCT03065335

This clinical trial is studying the effects of ketamine, a medication that has been shown to quickly help with depression, to see how it can be used more effectively. The main goal is to understand...

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

NCT ID: NCT00018057

This clinical trial is studying how different brain functions and clinical features relate to anxiety disorders in children and adolescents. The researchers are looking at how these features change...