Clinical Trials for Major Depressive Disorder

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT ID: NCT03065335

This clinical trial is studying the effects of ketamine, a medication that has been shown to quickly help with depression, to see how it can be used more effectively. The main goal is to understand...

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

NCT ID: NCT03973268

This clinical trial is studying how ketamine, a medication often used for depression, works in the brain. Researchers want to understand if the antidepressant effects of ketamine are linked to spec...

An Open-Label Study of Azetukalner in Major Depressive Disorder

NCT ID: NCT06922110

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

NCT ID: NCT06775379

This clinical trial, called X-NOVA2, is studying a new medication called azetukalner to see how well it works for adults with Major Depressive Disorder (MDD). The trial is designed for adults aged ...

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

NCT ID: NCT06633016

The AMPLIFY clinical trial is studying a new medication called ABX-002 to see if it can help improve symptoms of major depressive disorder in adults who are currently taking an antidepressant but a...

Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

NCT ID: NCT02046330

This clinical trial is studying a treatment called Deep Brain Stimulation (DBS) for people who have Major Depressive Disorder that hasn't improved with other treatments, known as treatment-resistan...

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

NCT ID: NCT06547489

This clinical trial, called GATE-251, is investigating whether a new medication can help treat major depressive disorder (MDD) in adults. The main goals are to see if GATE-251 can lower depression ...

Clinical Validation of Samsung Smartwatch

NCT ID: NCT05767593

This clinical trial is investigating a new feature developed by Samsung that aims to help monitor mental health, specifically focusing on detecting signs of depression and anxiety using a smartwatc...

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

NCT ID: NCT06820723

This clinical trial is exploring how a single dose of a psychedelic drug, related to psilocybin (found in certain mushrooms), might help people suffering from depression and anxiety. Specifically, ...

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

NCT ID: NCT07028216

This clinical trial is studying how different ways of delivering an 8-week Mindful Self-Compassion (MSC) program affect symptoms of anxiety and depression. MSC is a type of training that helps peop...

Open Label Optimization Study

NCT ID: NCT05819021

This clinical trial, called an Open Label Optimization Study, is looking at a new treatment option for people with Major Depressive Disorder (MDD) who haven’t found relief from current antidepressa...

Invasive Decoding and Stimulation of Altered Reward Computations in Depression

NCT ID: NCT05239780

This clinical trial is exploring new ways to treat major depressive disorder using advanced brain stimulation techniques. Researchers are specifically looking at areas of the brain that help contro...

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT ID: NCT06462196

This clinical trial is studying mood disorders like depression and bipolar disorder, which are often hard to treat effectively. Researchers are looking to understand how these conditions affect pat...

Mindful Self-Compassion for Anxiety Disorders and Depression

NCT ID: NCT05671419

This clinical trial is exploring how an 8-week program called Mindful Self-Compassion (MSC) can help individuals struggling with anxiety disorders and depression. The researchers want to see if thi...

Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

NCT ID: NCT03289923

This clinical trial is exploring a new way to treat major depression by combining brain stimulation with talk therapy. The researchers want to see if using brain scans (MRI) can help identify the b...

RESISTance Exercise for Depression Trial

NCT ID: NCT06110897

The RESISTance Exercise for Depression Trial is studying how different levels of resistance exercise (like weight training) can help improve symptoms of Major Depressive Disorder (MDD). This trial ...

A Randomized Neuroimaging Trial of Psilocybin in Depression

NCT ID: NCT06072898

This clinical trial is studying how a substance called psilocybin, found in certain mushrooms, affects the brain activity of people with major depressive disorder. Researchers want to see if psiloc...

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

NCT ID: NCT00018057

This clinical trial is studying how different brain functions and clinical features relate to anxiety disorders in children and adolescents. The researchers are looking at how these features change...

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

NCT ID: NCT05051618

This clinical trial is studying how different exercise programs can help manage depression in people with multiple sclerosis (MS). Specifically, it will compare an exercise training program called ...

Aβ Dynamics in LLMD

NCT ID: NCT05004987

This clinical trial, called "Aβ Dynamics in LLMD," is studying the link between depression and Alzheimer's disease (AD). Researchers want to understand how treating depression might affect biologic...