Clinical Trials for Major Depressive Disorder

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT ID: NCT03065335

This clinical trial is studying the effects of ketamine, a medication that has been shown to quickly help with depression, to see how it can be used more effectively. The main goal is to understand...

Study to Assess the Safety and Effectiveness of NMRA-335140-501

NCT ID: NCT06029439

This clinical trial, named NMRA-335140-501, is studying a new treatment called NMRA-335140 for people with Major Depressive Disorder (MDD). It is an extension of previous studies that looked at how...

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

NCT ID: NCT06705478

This clinical trial is studying two medications, pramipexole and escitalopram, to see which one is more effective and safe for treating major depressive disorder (MDD) in people living with HIV, es...

Antidepressant Response of DMT Masked With Propofol

NCT ID: NCT06927076

This clinical trial is studying the effects of a substance called N,N-dimethyltryptamine (DMT) on individuals with Major Depressive Disorder (MDD). The researchers want to find out if DMT helps red...

Mechanisms of Rumination Change in Adolescent Depression

NCT ID: NCT03859297

This clinical trial is studying a new type of treatment called rumination-focused cognitive behavioral treatment (RF-CBT) for adolescents with depression. This approach combines mindfulness techniq...

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

NCT ID: NCT06564818

This clinical trial is studying a new treatment called CYB003, which is a type of psilocybin analog, for people with Major Depressive Disorder (MDD). The goal of the study is to see if CYB003 is ef...

Decoding and Modulating Affective Brain States

NCT ID: NCT05437705

This clinical trial, titled "Decoding and Modulating Affective Brain States," is exploring ways to help individuals who struggle with feelings of sadness, worry, and negative thoughts, particularly...

Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

NCT ID: NCT06979154

The clinical trial called "Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression" (or PandA-tACS) is looking at a new treatment for women experi...

Defining Neurobiological Links Between Substance Use and Mental Illness

NCT ID: NCT05538910

This clinical trial is studying how nicotine affects people with major depressive disorder (MDD) and how it relates to their brain function. Researchers want to learn more about why people with MDD...

Clonidine to Prevent Delirium After Electroconvulsive Therapy.

NCT ID: NCT04828226

This clinical trial is studying whether a medication called clonidine can help prevent agitation and confusion (called delirium) that some patients experience after undergoing electroconvulsive the...

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

NCT ID: NCT05172271

This clinical trial is studying a new treatment called Transcranial Electric Stimulation Therapy (TEST) for people who have major depression and haven’t found relief from current treatments. The go...

Psilocybin-assisted CBT for Depression

NCT ID: NCT05227612

This clinical trial is exploring the use of psilocybin, a substance found in certain mushrooms, combined with cognitive-behavioral therapy (CBT) to help people with major depressive disorder. The s...

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder With Comorbid Anxiety and Insomnia

NCT ID: NCT07115329

This clinical trial is studying a new medication called GATE-251 to see if it can help reduce symptoms of major depressive disorder (MDD) in adults who also have anxiety and trouble sleeping. The s...

5-HTP and Creatine for Depression R33 Phase

NCT ID: NCT05895747

This clinical trial is studying the effects of two supplements, 5-hydroxytryptophan (5-HTP) and creatine, on people with major depressive disorder (MDD). The trial will involve three groups: one wi...

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

NCT ID: NCT07111390

This clinical trial is exploring a new treatment for adults with Major Depressive Disorder (MDD), a type of depression. The study is testing whether using a special light therapy at home can be saf...

Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

NCT ID: NCT03289923

This clinical trial is exploring a new way to treat major depression by combining brain stimulation with talk therapy. The researchers want to see if using brain scans (MRI) can help identify the b...

Mindfulness Engaged Neurostimulation for Depression

NCT ID: NCT06399406

This clinical trial is studying a new treatment approach for people with treatment-resistant depression, which means their depression hasn't improved with standard medications. The trial combines a...

Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics

NCT ID: NCT05910957

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

NCT ID: NCT06966401

This clinical trial is studying a new medication called NBI-1065845 to see how safe it is and how well people can tolerate it when used alongside other treatments for Major Depressive Disorder (MDD...

Positive Processes and Transition to Health (PATH)

NCT ID: NCT06093906

The PATH trial is researching how different therapies can help people who have experienced a traumatic event and are dealing with symptoms of Posttraumatic Stress Disorder (PTSD) or Major Depressiv...