A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

NCT ID: NCT05581004

This clinical trial is testing a new treatment called RO7502175, both on its own and in combination with another medication called atezolizumab. The study is designed for adults who have locally ad...

Recruiting

Phase: PHASE1 Type: interventional Locations: Detroit, Michigan, United States, Atlanta, Georgia, United States +44 more

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

NCT ID: NCT06607185

This clinical trial is studying a new medication called LY4066434, which is designed to target specific mutations in a gene called KRAS found in certain types of cancer. The trial focuses on patien...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Durham, North Carolina, United States +74 more

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

NCT ID: NCT06562192

This clinical trial is studying a new treatment called [177Lu]Lu-NNS309 for patients with advanced stages of certain types of cancer, including pancreatic, lung, breast, and colorectal cancers. The...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Stanford, California, United States +9 more

Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial

NCT ID: NCT07071987

This clinical trial is studying whether a treatment called thread embedding acupuncture (TEA) can help people recover faster after surgery for colorectal cancer, which affects the colon or rectum. ...

Recruiting

Phase: NA Type: interventional Locations: Yangzhou, Jiangsu, China

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

NCT ID: NCT05538130

This clinical trial is studying a new medicine called PF-07799544 to see how safe and effective it is for people with advanced solid tumors, such as melanoma, brain cancer, thyroid cancer, and lung...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Detroit, Michigan, United States +53 more

Personalized Health Self-Management Training for Colorectal Cancer Survivors

NCT ID: NCT05984589

This clinical trial is comparing two types of self-management training programs for patients with colorectal cancer. The goal is to find out if a personalized self-management training (PSMT) progra...

Recruiting

Phase: NA Type: interventional Locations: Los Angeles, California, United States, Los Angeles, California, United States

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

NCT ID: NCT06105021

This clinical trial is studying a new treatment called AFNT-211 for patients with advanced solid tumors that have a specific genetic change known as the KRAS G12V mutation. This mutation is commonl...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Nashville, Tennessee, United States +10 more

A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer

NCT ID: NCT06410534

This clinical trial is studying the effects of two approved medications, nivolumab and ipilimumab, to see if they can help people with colorectal or gastroesophageal cancer avoid or delay major sur...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)

NCT ID: NCT06603818

This clinical trial is exploring a new treatment approach for patients with microsatellite stable metastatic colorectal cancer (mCRC), which is a type of cancer that has spread beyond the colon and...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

NCT ID: NCT06690281

This clinical trial is studying a new type of treatment called T-cell therapy for patients with advanced gastrointestinal (GI) cancers, such as pancreatic, liver, and colorectal cancers. The goal i...

Recruiting

Phase: PHASE2 Type: interventional Locations: Bethesda, Maryland, United States

Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]

NCT ID: NCT07071961

This clinical trial is studying a new treatment approach for people with colorectal cancer who are considered high risk for their cancer returning after completing standard therapy, such as surgery...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Houston, Texas, United States

CT-95 in Advanced Cancers Associated With Mesothelin Expression

NCT ID: NCT06756035

This clinical trial is studying a new treatment called CT-95 for patients with advanced cancers that express a protein called mesothelin. Mesothelin is found in certain types of tumors, including a...

Recruiting

Phase: PHASE1 Type: interventional Locations: San Antonio, Texas, United States, Hackensack, New Jersey, United States +4 more

Anti-CEACAM5 ADC M9140 in Chinese Participants With Solid Tumors (PROCEADE-CRC-02)

NCT ID: NCT06806046

This clinical trial, called PROCEADE-CRC-02, is studying a new treatment called M9140 for Chinese participants who have advanced or metastatic colorectal cancer (CRC). The main goal of the trial is...

Recruiting

Phase: PHASE1 Type: interventional Locations: Beijing, , China, Beijing, Beijing, China +2 more

A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

NCT ID: NCT07020221

This clinical trial is studying a new treatment called VS-7375 for patients with certain types of advanced solid tumors that have a specific genetic change known as the KRAS G12D mutation. The goal...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Saint Louis, Missouri, United States +3 more

Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions

NCT ID: NCT07066046

This clinical trial is studying how well artificial intelligence (AI) can help doctors find and understand growths in the colon during a colonoscopy. A colonoscopy is a test where a doctor uses a s...

Recruiting

Phase: NA Type: interventional Locations: São Paulo, Sp, Brazil

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

NCT ID: NCT06445062

This clinical trial is studying a new type of treatment called RAS(ON) inhibitors for patients with certain types of gastrointestinal cancers, specifically colorectal cancer and pancreatic cancer. ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Philadelphia, Pennsylvania, United States +22 more

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

NCT ID: NCT06428409

This clinical trial is investigating a new treatment called sacituzumab tirumotecan (MK-2870) to see how well it works alone or in combination with chemotherapy for certain advanced gastrointestina...

Recruiting

Phase: PHASE1 Type: interventional Locations: Brisbane, Queensland, Australia, Fuzhou, Fujian, China +58 more

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

NCT ID: NCT03998202

This clinical trial is investigating how low muscle mass, also known as myopenia, affects older adults with advanced colorectal cancer when they receive chemotherapy. Researchers want to understand...

Recruiting

Type: observational Locations: Flint, Michigan, United States, Edina, Minnesota, United States +211 more

Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.

NCT ID: NCT06227728

This clinical trial is looking at how changes in certain blood markers can help doctors predict how well patients with advanced-stage cancer respond to a type of treatment called immunotherapy. Spe...

Recruiting

Type: observational Locations: Ho Chi Minh City, , Vietnam, Ho Chi Minh City, Hồ Chí Minh, Vietnam +1 more

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

NCT ID: NCT06253520

This clinical trial is exploring a new treatment for adults with advanced cancers that have spread, such as colorectal, breast, lung, gastrointestinal, ovarian, and genitourinary cancers. The goal ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Bethesda, Maryland, United States

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Clinical Trials for Colorectal Cancer

624 Active Trials Found

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial

A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

Personalized Health Self-Management Training for Colorectal Cancer Survivors

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer

Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]

CT-95 in Advanced Cancers Associated With Mesothelin Expression

Anti-CEACAM5 ADC M9140 in Chinese Participants With Solid Tumors (PROCEADE-CRC-02)

A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

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