Clinical Trials for Sickle Cell Disease

Find clinical trials for sickle cell disease. Discover research opportunities and treatment options in your area.

177 Active Trials Found

Showing 177 trials on this page

Page 1 of 9

Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation

NCT ID: NCT04093986

This clinical trial is exploring how exposure to a medication called hydroxyurea affects women with sickle cell disease (SCD) during pregnancy and breastfeeding, as well as how it impacts their bab...

Recruiting

Type: observational Locations: Cincinnati, Ohio, United States

Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

NCT ID: NCT00047996

This clinical trial is studying how blood samples from people with sickle cell disease and healthy volunteers can help researchers understand diseases related to blood vessels better. By collecting...

Enrolling by invitation

Type: observational Locations: Bethesda, Maryland, United States, Fairfax, Virginia, United States

A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke

NCT ID: NCT05953584

This clinical trial is investigating a new medication called etavopivat, aimed at helping children with sickle cell disease (SCD) who are at higher risk of having a stroke. The trial will involve c...

Recruiting

Phase: PHASE2 Type: interventional Locations: New Delhi, Delhi, India, Muscat, , Oman +18 more

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

NCT ID: NCT06612268

This clinical trial is testing a new medication called etavopivat to see how well it helps people with sickle cell disease. Specifically, the study aims to find out if etavopivat can reduce painful...

Recruiting

Phase: PHASE3 Type: interventional Locations: Minneapolis, Minnesota, United States, Durham, North Carolina, United States +179 more

Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

NCT ID: NCT05583721

This clinical trial is studying how reduced blood flow to the heart might be related to heart problems in people with Sickle Cell Disease (SCD). Specifically, researchers want to understand if this...

Recruiting

Phase: PHASE2 Type: interventional Locations: Memphis, Tennessee, United States

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

NCT ID: NCT06439082

The SPARKLE trial is a clinical study looking at a new treatment called crizanlizumab for patients with sickle cell disease (SCD) who often experience painful episodes known as vaso-occlusive crise...

Recruiting

Phase: PHASE3 Type: interventional Locations: Jacksonville, Florida, United States, Greenville, North Carolina, United States +9 more

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

NCT ID: NCT05170412

This clinical trial is looking at how diet and eating habits affect the health of adults with Sickle Cell Disease (SCD). SCD is a condition where blood cells become crescent-shaped, which can lead ...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

NCT ID: NCT02447874

This clinical trial is studying whether giving extra arginine, an amino acid, can help reduce pain in children with sickle cell disease during painful episodes, known as vaso-occlusive events. The ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Atlanta, Georgia, United States, Atlanta, Georgia, United States +1 more

Blood Sampling for Research Related to Sickle Cell Disease

NCT ID: NCT00542230

This clinical trial is focused on studying sickle cell disease, a condition that affects how red blood cells work and limits their ability to carry oxygen in the body. Researchers want to collect b...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States, Bethesda, Maryland, United States

Exercise in Child Health

NCT ID: NCT05359991

The "Exercise in Child Health" clinical trial is studying how children with certain chronic illnesses—like cystic fibrosis, sickle cell disease, and those who have had SARS-CoV-2 infections—respond...

Recruiting

Phase: NA Type: interventional Locations: Irvine, California, United States

The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease

NCT ID: NCT06975865

This clinical trial is studying a new medication called rilzabrutinib to see how effective and safe it is for people aged 10 to 65 years who have sickle cell disease (SCD). Sickle cell disease is a...

Recruiting

Phase: PHASE3 Type: interventional Locations: London, London, City Of, United Kingdom, Hialeah, Florida, United States +2 more

Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

NCT ID: NCT04657822

This clinical trial is a rollover study for patients with Sickle Cell Disease (SCD) who have previously participated in a study sponsored by Novartis and have been receiving a medication called cri...

Recruiting

Phase: PHASE4 Type: interventional Locations: Birmingham, Alabama, United States, Greenville, North Carolina, United States +42 more

Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

NCT ID: NCT06555939

This clinical trial is focused on helping adolescents and young adults with sickle cell disease (SCD) improve their mental well-being and resilience. The study will test a new program called PRISM,...

Not yet recruiting

Phase: NA Type: interventional

Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/βC Genotype

NCT ID: NCT05951205

This clinical trial is looking at a new treatment called exa-cel for people with severe sickle cell disease, specifically those with a certain genetic type known as βS/βC genotype (HbSC). The main ...

Not yet recruiting

Phase: PHASE3 Type: interventional

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

NCT ID: NCT03937817

This clinical trial is focused on collecting samples from individuals with blood disorders, such as sickle cell disease and thalassemia, as well as healthy volunteers. The aim is to gather biologic...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

NCT ID: NCT06944067

This clinical trial is looking to understand how our genes might affect the way some people with sickle cell disease respond to blood transfusions. Specifically, it's focusing on a type of immune r...

Recruiting

Type: observational Locations: Bethesda, Maryland, United States

Cannabidiol in Sickle Cell Disease

NCT ID: NCT06930703

This clinical trial is studying the effects of a medication called cannabidiol (CBD) in adults with Sickle Cell Disease (SCD). The trial aims to find out if different doses of CBD (200mg, 400mg, an...

Recruiting

Phase: PHASE1 Type: interventional Locations: Manhattan, New York, United States

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

NCT ID: NCT06385886

The RECIPE trial is studying how to improve care for people living with Sickle Cell Disease (SCD) who have not seen a specialist in the last year. Researchers want to find the best ways to connect ...

Recruiting

Type: observational Locations: Philadelphia, Pennsylvania, United States, Phoenix, Arizona, United States +7 more

A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)

NCT ID: NCT06924970

This clinical trial is studying a medication called tebapivat to see how well it works in treating anemia in people with Sickle Cell Disease (SCD). Anemia is a condition where you don’t have enough...

Recruiting

Phase: PHASE2 Type: interventional Locations: Washington, District Of Columbia, United States, New York, New York, United States

A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy

NCT ID: NCT06286046

This clinical trial is studying a medication called mitapivat to see how it affects kidney health in people with sickle cell disease (SCD) who also have nephropathy, which is a condition that affec...

Not yet recruiting

Phase: PHASE2 Type: interventional

Related Conditions

Breast Cancer View clinical trials → Stroke View clinical trials → Obesity View clinical trials → Cancer View clinical trials → Healthy View clinical trials → Prostate Cancer View clinical trials →

Search All Trials Browse All Conditions