Clinical Trials in Hot Springs, Arkansas

Find clinical trials in Hot Springs, Arkansas. Discover local research opportunities and treatment options in your area.

50 Active Trials Found in Hot Springs

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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

NCT ID: NCT03866382

This clinical trial is investigating how well three medications—cabozantinib, nivolumab, and ipilimumab—work together to treat patients with rare genitourinary tumors that have spread to other part...

Recruiting

Phase: PHASE2 Conditions: Stage IVB Prostate Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8 +43 more

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

NCT ID: NCT04267848

The ALCHEMIST trial is a clinical study looking at whether adding a drug called pembrolizumab, which is a type of immunotherapy, to standard chemotherapy can improve treatment outcomes for patients...

Recruiting

Phase: PHASE3 Conditions: Stage IIIB Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8 +4 more

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)

NCT ID: NCT06516952

This clinical trial is studying a new medication called povorcitinib to see how well it helps people with prurigo nodularis, a condition that causes intense itching and skin bumps. The main goal is...

Recruiting

Phase: PHASE3 Conditions: Prurigo Nodularis

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

NCT ID: NCT06548360

This clinical trial is studying a new cream called ruxolitinib to see if it is safe and effective for children with nonsegmental vitiligo, a condition where patches of skin lose their color. The tr...

Recruiting

Phase: PHASE3 Conditions: NonSegmental Vitiligo

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

NCT ID: NCT06646276

This clinical trial, called TIGOS, is studying a new treatment for people with Extensive-Stage Small Cell Lung Cancer (ES-SCLC). The researchers want to compare two treatment combinations: one that...

Recruiting

Phase: PHASE3 Conditions: Extensive-Stage Small Cell Lung Cancer

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

NCT ID: NCT06855498

This clinical trial is a continuation study for people who have already participated in earlier studies involving a medication called povorcitinib, which is being tested for a skin condition known ...

Recruiting

Phase: PHASE3 Conditions: Hidradenitis Suppurativa (HS)

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

NCT ID: NCT04269902

**Summary of the EVOLVE CLL/SLL Study** The EVOLVE CLL/SLL study is a clinical trial designed to find out if starting treatment for high-risk chronic lymphocytic leukemia (CLL) or small lymphocyti...

Recruiting

Phase: PHASE3 Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

NCT ID: NCT05882877

This clinical trial is studying a medication called rocatinlimab to see how safe it is and how well it works for people aged 12 and older who have moderate to severe atopic dermatitis, which is a t...

Recruiting

Phase: PHASE3 Conditions: Atopic Dermatitis

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

NCT ID: NCT04181060

This clinical trial is studying the effects of two treatments for patients with advanced non-small cell lung cancer that has a specific gene change called an EGFR mutation. Researchers want to find...

Recruiting

Phase: PHASE3 Conditions: Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 +3 more

Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

NCT ID: NCT04548752

This clinical trial is exploring whether combining an immunotherapy drug called pembrolizumab with a cancer treatment called olaparib can work better than olaparib alone for patients with metastati...

Recruiting

Phase: PHASE2 Conditions: Metastatic Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

NCT ID: NCT04579224

This clinical trial is looking at a new treatment for patients with metastatic urothelial cancer, which is a type of cancer that affects the bladder and other parts of the urinary system. Specifica...

Recruiting

Phase: PHASE3 Conditions: Metastatic Urothelial Carcinoma, Stage IV Bladder Cancer AJCC v8 +3 more

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

NCT ID: NCT04858334

The APOLLO trial is studying the effects of a medication called olaparib in patients who have had surgery for pancreatic cancer and have specific genetic mutations (in genes called BRCA1, BRCA2, or...

Recruiting

Phase: PHASE2 Conditions: Resectable Pancreatic Adenocarcinoma, Pancreatic Acinar Cell Carcinoma +5 more

A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

NCT ID: NCT05889182

This clinical trial is studying a medication called upadacitinib to see how effective and safe it is for treating moderate to severe hidradenitis suppurativa (HS) in adults and adolescents who have...

Recruiting

Phase: PHASE3 Conditions: Hidradenitis Suppurativa

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

NCT ID: NCT05125302

This clinical trial is studying a medication called ubrogepant to see how safe and effective it is for treating migraines in children and adolescents aged 6 to 17 years. Migraines can cause severe ...

Recruiting

Phase: PHASE3 Conditions: Migraine

Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations

NCT ID: NCT03609216

This clinical trial is looking at how well two chemotherapy drugs, gemcitabine and cisplatin, work for treating patients with a type of bladder cancer called muscle-invasive urothelial carcinoma. T...

Recruiting

Phase: PHASE2 Conditions: Infiltrating Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma +1 more

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

NCT ID: NCT06455202

This clinical trial is studying a new treatment called barzolvolimab for adults suffering from Chronic Spontaneous Urticaria (CSU), which is a condition where people experience itchy hives without ...

Recruiting

Phase: PHASE3 Conditions: Chronic Spontaneous Urticaria

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT ID: NCT05254743

This clinical trial is comparing two medications, pirtobrutinib (also known as LOXO-305) and ibrutinib, to see which one is more effective and safer for people with Chronic Lymphocytic Leukemia (CL...

Recruiting

Phase: PHASE3 Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma +2 more

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

NCT ID: NCT05296798

This clinical trial, called the heredERA Breast Cancer study, is looking at the effectiveness and safety of a new medication called giredestrant when combined with Phesgo (which includes pertuzumab...

Recruiting

Phase: PHASE3 Conditions: Locally Advanced or Metastatic Breast Cancer

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

NCT ID: NCT05059444

The ORACLE trial is investigating a new blood test developed by Guardant Health that looks for small pieces of cancer DNA in the blood, known as ctDNA, in patients who have been treated for early-s...

Recruiting

Conditions: Non-small Cell Lung Cancer, Renal Cell Carcinoma +14 more

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

NCT ID: NCT03937635

This clinical trial is studying how effective a combination of three medications—lenalidomide, dexamethasone, and daratumumab—are in treating patients with high-risk smoldering myeloma. Smoldering ...

Recruiting

Phase: PHASE3 Conditions: Smoldering Plasma Cell Myeloma