Clinical Trials for Down Syndrome

Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

NCT ID: NCT05301361

Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.

NCT ID: NCT07044804

This clinical trial is studying a new way to help improve language skills in teenagers and young adults with Down syndrome. The treatment uses a gentle, non-invasive brain stimulation called transc...

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

NCT ID: NCT04546399

This clinical trial is studying a new way to treat children and young adults who have a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back after initial trea...

Trial-Ready Cohort-Down Syndrome (TRC-DS)

NCT ID: NCT04165109

The Trial-Ready Cohort - Down Syndrome (TRC-DS) is a research study aimed at understanding how Alzheimer's disease affects adults with Down syndrome, helping to prepare for future clinical trials. ...

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease

NCT ID: NCT06206824

This clinical trial is studying a new medication called Leucettinib-21 to see how safe it is and how it works in the body. The trial has four parts: the first two parts involve healthy men aged 18 ...

Nutritional Status in Children With Down Syndrome

NCT ID: NCT06989060

This clinical trial is looking to understand the nutritional status of children with Down syndrome. Researchers want to find out how well these children are eating and whether they have any nutriti...

Effects of Down Dog Yoga on Pre-writing Skills in Children With Down Syndrome

NCT ID: NCT06977672

This clinical trial is looking at how practicing Down Dog Yoga can help improve pre-writing skills in children with Down Syndrome, a condition that affects their physical and mental development. Th...

Brain Outcomes With Lifestyle Change in Down Syndrome

NCT ID: NCT05985486

This clinical trial, called "Brain Outcomes With Lifestyle Change in Down Syndrome," is studying whether weight loss can help adults with Down syndrome delay or prevent the development of Alzheimer...

Measuring Aided Language Development

NCT ID: NCT06512168

This clinical trial, titled "Measuring Aided Language Development," aims to understand how well certain communication tools work for children with conditions like Down Syndrome, Cerebral Palsy, and...

Harness-based Mobility Intervention for Infants With Down Syndrome

NCT ID: NCT06219863

This clinical trial is exploring a new way to help infants with Down syndrome (DS) learn to crawl and walk. Infants with DS often take longer to develop these important skills, which are crucial fo...

Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)

NCT ID: NCT06673069

The HERO study is looking at a new treatment called ION269 to see if it is safe and well-tolerated for adults with Down syndrome who are at risk for Alzheimer's disease. The main goal is to underst...

The Effects Of "Minds In Motion The Maze" on Balance and Gate In Children With Down Syndrome

NCT ID: NCT06955052

This clinical trial is studying how a program called "Minds In Motion: The Maze" can help improve balance and walking skills in children with Down syndrome. Children aged 8 to 12 who have the physi...

How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

NCT ID: NCT06951516

This clinical trial is studying how different ways of using language can help young children with Down syndrome learn and understand better. Specifically, researchers want to see if using single wo...

Down Syndrome Obstructive Sleep Apnea

NCT ID: NCT06043440

This clinical trial is investigating whether giving extra oxygen during sleep can help improve memory and other important health outcomes for children and teenagers with Down Syndrome who also have...

Nordic Walk on Balance and Functional Strength in Children With Down Syndrome

NCT ID: NCT06943508

This clinical trial is studying the effects of Nordic walking on balance and strength in children with Down syndrome. Down syndrome is a genetic condition that can affect a child's physical and men...

Effects of Interactive Sensory Play on Manual Dexterity in Down Syndrome

NCT ID: NCT06943352

This clinical trial is studying how interactive sensory play can help improve hand movements, known as manual dexterity, in children with Down Syndrome. Down Syndrome is a genetic condition that ca...

Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome

NCT ID: NCT06943170

This clinical trial is studying how aerobic exercise affects weight and body fat in children with Down syndrome. Researchers want to find out if combining aerobic exercise with a low-calorie diet h...

Effects of Task-oriented Training on Visual-motor Integration and Upper Limb Function in Children With Down Syndrome

NCT ID: NCT06943261

This clinical trial is studying how a specific type of training, called task-oriented training, can help improve hand and eye coordination and upper limb function in children with Down Syndrome. Ch...

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

NCT ID: NCT05702645

This clinical trial is looking to understand the long-term health of individuals with Down syndrome who have been treated for acute leukemia, a type of blood cancer. Researchers want to find out mo...

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

NCT ID: NCT05508971

The TOPS-DS trial is studying a new way to treat obstructive sleep apnea (OSA) in children with Down syndrome. OSA is a condition where a child's breathing is interrupted during sleep, and it can l...